NMN supplements are marketed as a method to aid your body in turning back time but what amount should you take?
Wouldn’t it be great to set our body’s clock few steps? It seems that we have the ability to at the very least, slow the clock down thanks to increasing numbers of supplements that can increase the production of NAD+ within the body. Although each supplement makes big claims but do they really have any benefit and what are the possible adverse impacts?
What’s NMN?
NMN, also known as nicotinamide mononucleotide is a precursor for an essential molecule , NAD+. Studies have shown that, not only is NAD+ supply the energy needed to function, develop and repair it can also play a role in halting the ageing process.
As we age your body is naturally vulnerable to various ailments and heart diseases, obesity and a host of other issues. This is in line with the declining NMN as well as NAD+ levels as documented by studies; in reality when we reach 50, we’ve only less than half the amount NMN that we had in our 20s.
NAD+ is used by enzymes and proteins which play an essential function in the repair of DNA damage as well as fueling our cells and keeping our immune and metabolic systems functioning well. However, it’s not just about keeping our systems in good shape and systems NAD+ could be the key to stopping age-related decline.
If we can maintain NAD+ levels at a reasonable level and we can slow down the aging process , and at times gradually slowing it down slightly. This is the point where NMN is a factor. It is a NAD+ precursor that the body utilizes to restore young levels of NAD+.
The benefits of NMN supplements
Research into NMN is ongoing which includes rodent as well as human studies. The research so far has offered a few indications of NMN benefits, which include:
Increased levels of NMN boost the metabolism, which improves the body’s capacity to convert food into energy. This can aid in decreasing the likelihood of being obese. However, this should be done along with a healthy lifestyle and a healthy diet.
Lowering the risk of heart illness: The heart functions continuously throughout your day without taking a break. It is a major source of energy and will require every ounce of NADplus it could.
Improved metabolic diseases The early research suggests that NAD precursors can help in reducing body weight, mitigate the negative effects of diets high in fat and increase energy levels. A small study examined the effects on NMN on women suffering from prediabetes. The results showed that the muscles’ capacity to process sugar increased.
Enhancing fitness and endurance of muscles Muscles and bones require glucose and fatty acids to keep functioning. NAD+ helps them to be metabolized by the system. Without it, the system gets slower and endurance diminishes. A recent study on amateur runners also revealed that NMN improves human aerobic capacity. Researchers suggest that this may be due to increased oxygen consumption in the skeletal muscles.
Improving cognitive function: Research models of Alzheimer’s disease demonstrated improved memory and cognition after NMN supplementation. This is probably due to NAD+’s capacity to boost many vital functions of the brain.
Improved symptoms of serious illness Researchers are also examining the particular benefits of higher NAD levels in high blood pressure, liver health , and diabetes.
In our bodies, NAD+ produced through NMN supplements boosts the mitochondria’s activities microorganelles, which are essential for our metabolism. The cells’ powerhouses mitochondria transform oxygen and glucose into cell energy. Without mitochondria, cells would be deficient in energy and eventually die.
NAD+ also stimulates sirtuins a group of proteins which repair DNA and regulate the homeostasis of our cells. Every time cells divide, the caps at those ends of DNA are smaller; the fraying and shrinking of our DNA causes damage to our DNA. However, sirtuins help to slow down this process by stabilising the caps, also known as telomeres. Research in mice has shown the feeding of NMN can prolong telomeres, decreasing the chance of DNA damage.
It’s important to remember how sirtuins can be NAD dependent, meaning that they are unable to function without NAD. But when NAD production rises the sirtuin activity.
The side adverse effects of NMN supplements
Certain NAD boost supplements that are taken in high doses – have been linked to negative side effects, such as diarrhoea, nausea flushing, stomach discomfort and stomach discomfort. However, participants in studies involving NMN supplements have not reported adverse effects of any kind at doses as high as 1,200 mg.
For studies conducted in clinical settings, one study conducted in Japan discovered no adverse effects in doses as high as 500mg. Another study of endurance found no problems at doses as high as 1200 mg. One of the latest clinical trials used NMN supplements with placebo, 300 600, 900, and 300 mg doses, and found no evidence of toxicity at any dosage. The research is ongoing however, there aren’t at present any major safety concerns regarding NMN supplements.
The most significant safety issue, however, is the amount counterfeit and low-quality imitations that are available. The products available offer the same promises but for less than the price. Some of these aren’t completely NMN. Instead, they’ve been diluted with other compounds . This creates security concerns, particularly in the event that the manufacturer hasn’t clarified what is included.
This is especially true if an organization manufactures its NMN in facilities that are not cGMP certified which have more risk of contamination. Remember that , in the US, NMN is considered as a nutritional supplement, and therefore does not require to be verified safe and effective prior to it is released for sale. In contrast, NMN supplements are subject to postmarket oversight from The Food and Drug Administration – This means that customers need be wary of brands they consider reliable.
Knowing the manufacturing process can help as well. There are three standard methods to manufacture NMN
Chemical synthesis: labor-intensive and costly, this process results in a high yield and permits the precise control of the raw materials used even though none of them originates through biological processes. It uses environmentally-damaging solvents and impurities and byproducts in the finished product can be difficult to remove.
Enzymatic synthesis is costly, yet it produces more yield and high quality. It’s considered to be a green process to make NMN.
Fermented biosynthesis isn’t suitable for commercial production since it has low yields, but excellent quality.
To ensure safety, look for reputable brands that have transparency in their manufacturing processes and that have been independently vetted.
Instead of focusing on security, however most people are focused more on the cost of their products and comprehending the amount of NMN is required to get the desired result. Because NMN is extremely difficult to make and is so difficult to manufacture, the products are rather expensive. It is therefore important to take only all the NMN you can and nothing more.
Ideal dosage
Although there are no adverse reactions observed, there is no consensus regarding the appropriate dose of NMN. The majority of studies conducted to date have examined small doses. However, experts in longevity like Drs. Sinclair and Salzman believed that higher doses could yield more benefits. The clinical study that was conducted in 2022 evaluating outcomes of placebo 300 600, 900, and 300 mg doses showed the highest effectiveness in the 900mg dose. The endurance study that tested doses of 200,300,600 and 1,200mg daily observed the most significant effects on the high and medium groups, and averages out to the daily dose of 900 mg.
Supplement manufacturers will typically make their own recommendations regarding the proper dosages based on their personal findings and research. Some suggest changing the doses according to weight with higher doses recommended for people who weigh more.
Supplements for NMN are usually available in doses ranging from 100mg to 500mg. The dosages are usually between two and six tablets. Examine the label on the manufacturer’s website to find out how much they recommend you take.
The clinical knowledge about NMN supplements is constantly developing, with every trial and study increasing our knowledge just a more. What the research has revealed to date is that it seems to provide real advantages in terms of longevity and health. It also shows that the adverse effects are limited.